6-Chloro-5-cyclohexylindan-l-carboxylic Acid (TAI-284), a New Antiinflammatory Agent

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Biological activities of metabolites of 6-chloro-5-cyclohexylindan-1-carboxylic acid (TAI-284: anti-inflammatory agent).

The pharmacological activities of five metabolites of an anti-inflammatory compound, 6-chloro-5-cyclohexylindan-1-carboxylic acid (TAI-284) were investi gated and compared with TAI-284 and phenylbutazone. The metabolite IIb (cis 3'-hydroxy-cyclohexyl, β-form) was almost equivalent to TAI-284 regarding anti inflammatory activity as estimated by the carrageenin edema test, and was mor...

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In the title compound, C(5)H(5)NO(3), the mol-ecule lies on a crystallographic mirror plane with one half-mol-ecule in the asymmetric unit. An intramolecular C-H⋯O inter-action is present. In the crystal, strong inter-molecular O-H⋯N hydrogen bonds result in the formation of a linear chain structure along [100], and there are also weak C-H⋯O hydrogen bonds between the chains which help to stabi...

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ژورنال

عنوان ژورنال: Chemical and Pharmaceutical Bulletin

سال: 1971

ISSN: 0009-2363,1347-5223

DOI: 10.1248/cpb.19.646